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Aflatrol - Mycotoxin Binder

 Chicken Broilers Feeds

Chicks What is UT-Aflatrol?    

Aflatrol is presently showing a high potential for aflatoxin mycotoxin binding in animal feeds and field studies indicate other benefits from the effects of this product.

Aflatrol contains natural highly adsorbent montmorillonite layered silicate mineral clays and humified vegetable carbons with a honey comb pores structure, containing a myriad of substances found in several naturally occurring deposits of minerals produced by metamorphic and sedimentary activities of the earth's geology millions of years ago.

Aflatrol also contains MOS mannan oligosaccharides glucomannans and fructose oligosaccharides, dried lactobacillus acidophilus whey fermentation solubles combined with specific botanical herbal extracts known for their nutraceutical effects in animal feeds.

The ingredients contained in Aflatrol are not affected by high extrusion temperatures or pelleting

Mycotoxins Aflatoxin Animal FeedsThe ingredients contain aggregate forming molecules that act as chelating agents which can mobilize nutrients across various tissue membranes, thereby increasing the bio-availability of nutrients, especially minerals within the animals feed. These nutrients are often complexed (tied-tip) by such agents phytates and phosphates etc.

In addition to the benefits associated with the physical dynamics of UT-Alphatrol Premix, it also provides a nutrient-dense source of rare, naturally chelated macro and micro nutrients which are no longer readily supplied by various feed-stuffs due to soil depletion and processing methods.

Alphatol is a source of biosis factors, pathogen inhibition resulting from the addition lactobacillus acidophilus whey fermentation solubles rich in lactic acid, lactose, amino acids and other undefined nutrient factors (U.N.F's.) created during the fermentation process.

Effects of Mycotoxins in Animal Feeds (NC State University)

Swine

Swine Sows Piglets FeedsSwine are sensitive to mycotoxins, especially nursing or nursery-age swine. In general, mycotoxins cause reductions in feed intake, growth performance, and immune function when levels are relatively low. Producers must be aware that if one toxin is identified in a sample, the chances are high that other toxins are present. Some toxins may not have been identified as of yet, but research on known mycotoxins provides insight into the expected effects in swine and potential methods to reduce those effects. Table 3 contains a summary of the maximum permissible concentrations of mycotoxins in swine feeds.

Aflatoxin B1 has been the most extensively studied. Twenty to 200 ppb will cause a decrease in feed intake and growth performance, which can be partially offset by increasing specific dietary nutrients such as lysine or methionine. In severe cases (1,000 to 5,000 ppb) of aflatoxicosis, one can expect acute effects including death. Aflatoxin M1 appears in milk of sows consuming aflatoxin-contaminated diets and may affect piglets nursing those sows.

Feed concentrations of deoxynivalenol (DON) of 300 to 500 ppb are often associated with feed refusal, decreased weight gain, and increased incidence of infectious diseases. DON levels greater than 1000 ppb, will cause feed refusal or decrease in feed intake resulting in severe weight loss. It appears that pigs will often consume a sufficient amount of contaminated feed to induce vomiting. In fact, DON is also called vomitoxin because of its association with swine vomiting.

T-2 toxin has detrimental effects on swine performance, but no effect levels have not been determined for commercial production environments. However, field observations indicated that T-2 and related compounds are associated with decreased productivity at feed concentrations of 200 ppb or less.

Zearalenone will significantly affect the reproductive performance of swine. Prepuberal gilts are the most sensitive to zearalenone. The symptoms commonly observed when feeding diets contaminated with zearalenone include a reddening and increased size of the vulva, and increased size of mammary tissue. Zearalenone will cause embryonic mortality at certain stages of gestation. Fertility problems are often associated with zearalenone concentrations of 100 to 200 ppb in sow feeds.

Poultry

Chicken Broilers FeedsAflatoxin affects all poultry species. Although it generally takes relatively high levels to cause mortality, low levels can be detrimental if continually fed. Young poultry, especially ducks and turkeys, are very susceptible. As a general rule, growing poultry should not receive more than 20 ppb aflatoxin in the diet. However, feeding levels lower than 20 ppb may still reduce their resistance to disease, decrease their ability to withstand stress and bruising, and generally make them unthrifty.

Laying hens generally can tolerate higher levels than young birds, but levels should still be less than 50 ppb. Aflatoxin contamination can reduce the birds' ability to withstand stress by inhibiting the immune system. This malfunction can reduce egg size and possibly lower egg production. In addition, one must pay special attention to the use of contaminated corn in layer rations because eggs are promptly used as human food and aflatoxin metabolites have been found in egg yolks.

Mycotoxin levels found in most field situations tend to be low. Yet the combination of low levels of mycotoxins with the stresses associated with commercial production situations and/or exposure to disease organisms can produce effects in poultry which are subtle, indirect, and sometimes ill-defined. Since the effects of mycotoxins on poultry are dependant upon the age, physiological state, and nutritional status of the animals at the time of exposure, and since mold growth at various points within the feed production and distribution system can magnify mycotoxin problems, mycotoxicoses can be difficult to diagnose in field situations.

Mycotoxins produced by the mold genus Fusarium include: T-2 toxin and it's chemical relatives (trichothecenes), deoxynivalenol (DON), fumonisin, and zearalenone. Other animals tend to be more sensitive to the effects of fumonisin, deoxynivalenol, and zearalenone when compared to poultry. Nevertheless, detection of these mycotoxins within poultry rations indicates that the ration or the ingredients within the ration have been subjected to mold activity. Since numerous other mycotoxins, as well as reduced nutritive value and palatability of feeds, are generated by mold activity, the presence of fumonisin, deoxynivalenol, or zearalenone in poultry feeds is cause for concern.

T-2 toxin and trichothecenes can cause mouth and intestinal lesions as well as impair the birds' immune response, causing egg production declines, decreased feed consumption, weight loss, and altered feather patterns. While much is yet to be learned, T-2 toxin and related compounds are currently thought to be the most potent Fusarium mycotoxin for poultry.

DON alone has few effects in poultry. However, in field situations the DON level is sometimes associated with reduced feed consumption in layers and broiler breeders. This means that DON may be an indicator that T-2 or other unknown Fusarium mycotoxins are present.

Dairy Cattle   Agriculture Line

Aflatoxin-contaminated feed not only reduces animal performance and overall health, but it also creates risks of residues in milk. Aflatoxin is secreted into milk in the form of aflatoxin M1 with residues approximately equal to 1 to 2 percent (1.7 percent average) of the dietary level. This ratio is not influenced greatly by milk production level since higher producing cows consume more feed and have a slightly higher transmission rate. Due to risks of milk residues, dietary aflatoxin should be kept below 25 ppb. This level is conservative due to: (1) nonuniform distribution of aflatoxin in grain and feed, (2) uncertainties in sampling and analysis, and (3) the potential for having more than one source of aflatoxin in the diet. Replacement animals may tolerate 50 to 100 ppb aflatoxin.

In dairy cattle DON is associated with reduced feed intake, lower milk production, elevated milk somatic cell counts, and reduced reproductive efficiency. Milk production loss appears to occur when diets contain more than 300 ppb DON. Although controlled research has shown no cause and effect relationship between DON levels and reduced milk production, field observations have shown that reductions in milk output of 25 pounds per cow were seen when DON was 500 ppb or more. This suggests that DON may serve as a marker for feed that was exposed to a situation conducive to mold growth and mycotoxin formation. The possible presence of other mycotoxins, or factors more toxic than DON, seems likely. Dietary levels of 300 to 500 ppb DON in dairy feeds indicate mycotoxin problems and warrant attention.

Zearalenone causes estrogenic responses in dairy cattle, and large doses of this toxin are associated with abortions. Other responses of dairy animals to zearalenone may include reduced feed intake, decreased milk production, vaginitis, vaginal secretions, poor reproductive performance, and mammary gland enlargement in virgin heifers. Establishment of a tolerable level of zearalenone for dairy cattle is difficult, and is at best only a guess based on a meager amount of data and field observations. As with DON, zearalenone may serve as a marker for toxic feed. It is suggested that zearalenone not exceed 250 ppb in the total diet.

In dairy cattle T-2 toxin has been associated with feed refusal, production losses, gastroenteritis, intestinal hemorrhages, and death. T-2 has also been associated with reduced immune response in calves. Data with dairy cattle are not sufficient to establish a tolerable level of T-2 in the diet. Therefore, a practical recommendation may be to avoid T-2 in excess of 100 ppb in the total diet for growing or lactating dairy animals.

Fumonisin is another commonly isolated mycotoxin. However, fumonisin has only recently been isolated and only enough data exist to know that levels in excess of 20,000 ppb are potentially toxic to ruminants.

Beef Cattle

BeefAflatoxin and other mycotoxins can have considerable effects on beef cattle although the problems are usually less critical than for swine and poultry. Consumption of feeds highly contaminated with aflatoxin may reduce growth rate and increase the amount of feed required per pound of gain. Calves are generally more sensitive to feed contamination than adult cattle. In affected calves, some cases have revealed severe rectal straining and a prolapsed rectum. Lactating cows show a significant reduction in milk yield. Research has shown that high levels of aflatoxin can also cause liver damage in adult cattle. Feeding a high level of aflatoxin may also depress immune function, resulting in disease outbreaks.

Based on the feeds available, those contaminated with aflatoxin should be fed at the lowest level possible and for the shortest period of time practical. The effects of aflatoxin fed to cattle depend on the level of aflatoxin in the ration, the length of the feeding period, and the age of the animal. If aflatoxin-contaminated feeds must be fed to beef cattle, follow these guidelines (on a dry matter basis):

  1. Creep feeds and diets for gestating and lactating beef cows should contain less than 20 ppb of aflatoxin.
  2. Unstressed, growing-finishing cattle in excess of 400 pounds may be fed diets containing up to 100 ppb of aflatoxin.
  3. Diets for stressed feeder cattle should contain no more than 20 ppb of aflatoxin. Stressful conditions include weaning, shipping, extreme heat or cold, diseases, and parasites.
  4. Animals destined for slaughter should receive aflatoxin-free diets for at least 3 weeks before slaughter.

Since cattle in the southeast are typically fed high forage diets, they are usually fed grain only as a supplement. Thus a relatively high level of aflatoxin can occur in the grain before it exceeds the tolerable dietary level. In general, cattle will eat about 2.5 percent of their body weight as dry matter. This can be used to calculate the contribution of grain to their total ration, and the tolerable level of aflatoxin in the grain. For example, growing calves weighing 600 pounds will consume about 15 pounds of total feed (600 lb multiplied by 2.5% equals 15 lb). If they are fed 3 pounds of grain plus forage-to-appetite, the grain will make up about 20 percent of their total diet (3 lb divided by 15 lb equals 20%). In this case the grain may contain up to 500 ppb of aflatoxin (100 ppb divided by 20% equals 500 ppb). Aflatoxin levels allowable in the grain, given different rates of inclusion in the beef ration. (NC State University)

Aflatrol Research Test Results & Registrations

Aflatrol Test Results - Taiwan Registration No. 901032309 (Mycotoxin Binder)

(Binding Properties at 300g/ton/inclusion rate/% of reduction)

Aflatoxins........................... 90.0%     

T-2 Toxins .......................... 84.0%

Deoxynivalenol .................. 72.0%

Vomitoxin .......................... 71.0%

Citrin ................................. 63.0%

Rubratoxin ......................... 62.0%

Griseofulvin ........................ 55.0%

Zeralenone (F-2) ................ 49.0%

The above government test was conducted on corn and soya feed grains.

UT-Aflatrol is registered in Taiwan and many parts of Asia, Latin America, North America under private label and or / license agreements. Most of the compiled research on this product which we manufacture was compiled by our distributors.

Aflatrol 

General Indications: UT-Aflatrol potential benefits when added to animal feeds:

(1)    Binding of numerous mycotoxins
(2)    Helps reduce blood urea nitrogen  B.U.N.
(3)    Provides naturally chelated minerals
(4)    Normalize acid alkaline balance in gut
(5)    Stimulates production of digestive enzymes
(6)    Stimulates the growth and proliferation of beneficial intestinal flora
(7)    Improves feed conversion less fecal output with lower manure odors

Low economical inclusion rates (300g to 2 Kg/metric/ton or - 8 oz to 4 pounds)

General: Free Choice Cattle Cows Horses daily ration use 1/2 to 1 oz per/head/day  

Compatible with high temperature processing via extrusion/pelleting

UT-Aflatrol - 25 Kg Fiber Kegs or feed mill bulk 1 ton/tote/bags

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US FDA - Food Facility Registration # 12925762678

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